– Male, age 18 to 75 years
– BMI ≥17 to <40
– Documented primary or secondary hypogonadism
– Hypogonadal therapy naïve OR discontinued therapy with adequate washout
– Blood pressure <140/90 mmHg
– History of prostate or breast cancer
– Abnormal prostate exam or IPSS >19
– Severe heart failure, stroke, or MI in past 6 months- Severe untreated sleep apnea
– Current anticoagulant use
– Polycythemia or uncontrolled major illness